Free-breathing myocardial T2* mapping using GRE-EPI and MOCO for myocardial and hepatic iron overload assessment: a multi-centre study
نویسندگان
چکیده
Background T2* measurement is widely used in the assessment of patients at risk for cardiac and hepatic iron overload (1,2). The conventional breath-hold, ECG-triggered, segmented, multi-echo gradient echo sequence (BH MGRE) used for myocardial T2* quantification (3) is very sensitive to respiratory motion and may not be feasible in patients who are unable to breath-hold. To overcome this limitation, we developed a free-breathing myocardial T2* mapping approach (4). The goal of this study was to investigate the effectiveness of the new technique in patients referred for iron overload assessment at 4 different centers across the world.
منابع مشابه
Free-breathing myocardial T2* mapping using GRE-EPI and automatic Non-rigid motion correction
BACKGROUND Measurement of myocardial T2* is becoming widely used in the assessment of patients at risk for cardiac iron overload. The conventional breath-hold, ECG-triggered, segmented, multi-echo gradient echo (MGRE) sequence used for myocardial T2* quantification is very sensitive to respiratory motion and may not be feasible in patients who are unable to breath-hold. We propose a free-breath...
متن کاملMyocardial iron quantification using modified Look-Locker inversion recovery (MOLLI) T1 mapping at 3 Tesla
Background Quantification of myocardial iron overload is critical for the management of patients with hemochromatosis. The effects of excess iron on T1 and T2* relaxation times correlate directly with tissue iron concentration. T2* became the clinical standard at 1.5T as it can be easily obtained in a fast one breath-hold ECG gated multi-echo GRE sequence. At 3T, however, T2* quantification can...
متن کاملEvaluation of the relationship between hepatic and cardiac iron overload with MRI T2* and carotid intima media thickness with Doppler ultrasound in beta thalassemia major patients
Background: Iron overload is caused early progression of atherosclerosis in beta thalassemia patients due to regular repeated blood transfusion. MRI T2* is a gold standard non-invasive method for detecting hepatic and cardiac iron overload. The aim of this study was the comparison of carotid intima media thickness (CIMT) in the patients and healthy control groups with Doppler ultrasound for ear...
متن کاملFree-breathing myocardial T1 mapping using magnetization-prepared slice interleaved spoiled gradient echo imaging
Background Quantitative myocardial T1 mapping and extracellular volume fraction (ECV) show promise for non-invasive assessment of cardiomyopathies. Most available T1 mapping sequences use a single slice breath-hold acquisition with balanced steady state free precession (b-SSFP) readout [1]. However, b-SSFP readout is sensitive to B0 field inhomogeneity and is potentially T2 dependent [1]. In th...
متن کاملAssessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...
متن کامل